Diego E. Sastre, PhD, is an Assistant Professor in the Department of Biochemistry at the Emory University School of Medicine, where he studies the molecular mechanisms underlying enzymes that modify antibodies. His research integrates structural biology, molecular biophysics, protein engineering, and bioinformatics to define the principles governing antibody function and glycan-mediated interactions in physiological and pathological contexts.

Dr. Sastre’s work has advanced the understanding of bacterial endoglycosidases that selectively target IgG N-glycans, providing key mechanistic insights into enzyme specificity and substrate recognition. These findings establish a foundation for the development of precision therapeutics aimed at modulating pathogenic antibodies.

He is committed to translating fundamental discoveries into therapeutic innovation, with an emphasis on mechanism-driven design and scalability. Dr. Sastre is an inventor on multiple intellectual property filings supporting clinical development. His research program bridges basic and translational science, contributing to the next generation of biologics for immune-mediated diseases.

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